Figure 5.

Network gain is reduced in ClC-2 KO animals. A, B, Sample traces of extracellular field recordings for WT and KO in the absence (A) and presence (B) of picrotoxin. C, Input/output curve for basal synaptic transmission in hippocampal slices from WT (filled symbols) and KO (open symbols) mice. fEPSPs were recorded at a range of stimulus intensities from CA1 stratum radiatum. fEPSP slopes in the knock-out mice are significantly smaller than from WT mice at every fiber volley (FV) amplitude. D, Input/output curve in the presence of picrotoxin to block inhibition showed no significant differences between WT and KO. The slope of the I/O curve is increased compared with conditions without PTX for both WT and KO. Error bars represent SEM in all graphs. Note that symbol size might occlude error bars.