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. 2010 Jul 14;30(28):9368–9380. doi: 10.1523/JNEUROSCI.5987-09.2010

Figure 6.

Figure 6.

VGF infusion in the hippocampus reduces hyperactivity, and VGF +/− mice have increased response to amphetamine and do not respond to LiCl. A, Average ± SEM number of total crossings in 5 min bins. Mice were infused intrahippocampally with either saline (circles) or VGF (other shapes). Twenty-four hours later, the mice were acclimated to the open-field apparatus for 15 min, followed by intraperitoneal injection (indicated by arrow) of either amphetamine (filled symbols) or saline (open symbols). Total crossings were monitored for an additional 40 min (n = 5–7). *p < 0.05, VGF/d-amphetamine is significantly different from saline/d-amphetamine by ANOVA, Fisher's post hoc test. B, Average ± SEM number of total crossings in 5 min bins. WT (circles) and VGF heterozygote (VGF +/−) (squares) mice were acclimated to the open-field apparatus for 15 min, followed by intraperitoneal injection (indicated by arrow) of either amphetamine (filled symbols) or saline (open symbols). Total crossings were monitored for an additional 40 min (n = 6, 7). *p < 0.05, d-amphetamine VGF +/− is significantly different from saline/d-amphetamine WT by ANOVA, Fisher's post hoc test. C, VGF +/− mice do not respond to LiCl treatment. Average ± SEM number of total crossings in 5 min bins. Mice were given either saline (circles) or LiCl (other shapes) intraperitoneally. One hour later, the mice were acclimated to the open-field apparatus for 15 min, followed by intraperitoneal injection (indicated by arrow) of either amphetamine (filled symbols) or saline (open symbols). Total crossings were monitored for an additional 40 min (n = 6). *p < 0.05, LiCl/d-amphetamine VGF +/− is significantly different from LiCl/d-amphetamine WT by ANOVA, Fisher's post hoc test.