Table 2.

Stereological estimates of amyloid-β plaques in 9-month-old single and double transgenic AD mice

	app	reln/app	p
Hippocampus
Granular
Small	175 ± 84	224 ± 81	0.35
Medium	125 ± 45	249 ± 69	0.15
Large	0 ± 0	11 ± 4**	0.01
Fibrillar
Small	434 ± 161	1014 ± 313	0.15
Medium	247 ± 82	604 ± 175	0.20
Large	3 ± 2	38 ± 17*	0.04
Cortex layer I
Granular
Small	127 ± 57	158 ± 49	0.35
Medium	87 ± 31	194 ± 53	0.15
Large	0 ± 0	6 ± 3	0.08
Fibrillar
Small	514 ± 183	1142 ± 316	0.16
Medium	297 ± 86	600 ± 136	0.10
Large	5 ± 4	39 ± 17*	0.04
Cortex layers II–VI
Granular
Small	106 ± 42	105 ± 50	0.82
Medium	79 ± 32	114 ± 26	0.38
Large	3 ± 2	6 ± 5	0.99
Fibrillar
Small	382 ± 130	960 ± 279	0.11
Medium	243 ± 91	543 ± 113	0.06
Large	21 ± 13	42 ± 11	0.12

Values are presented as mean (±SEM) for the quantification of the estimated number of granular and fibrillary amyloid-β plaques, classified as either small (<25 μm), medium (25–75 μm), or large (>75 mm in diameter), and expressed as total number in the given brain area of app and reln/app (n = 8) subjects. Plaque counts in the hippocampus were performed along its entire septo-temporal axis; numerical estimates in the cortex included the piriform, lateral entorhinal, as well as the neocortex.

*p < 0.05,

**p ≤ 0.01.