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IGF-1 stimulates VEGF-A mRNA expression and protein secretion. A, Hippocampal neuron cultures were stimulated IGF-1 (300 ng/ml) for 6 h. Levels of HIF-1α and VEGF-A mRNA expression were analyzed by quantitative real-time PCR. B, Summary of experiments showing the time course of VEGF protein secretion in hippocampal neuron cultures treated with IGF-1. Data are presented as mean ± SEM. *p < 0.05 compared with the IGF-1 0 h (untreated) group by unpaired Student's t test.
