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. 2010 May 19;30(20):6921–6929. doi: 10.1523/JNEUROSCI.0238-10.2010

Figure 2.

Figure 2.

Evoked and spontaneous slow rising GABAergic currents for NG2 cells in the fourth PN week. a and b, Paired-pulse stimulation of neuronal fibers elicited inward currents in two NG2 cells held at −70 mV at PN8 (a) and PN24 (b), in the presence of 10 μm NBQX and 50 μm d-AP-5. Individual sweeps (gray) and averaged currents (black) are shown. Note the lack of failures of transmission in b. Evoked currents were sensitive to SR95531 (arrows) and reversed near 0 mV at both developmental stages (insets: single traces at −70 mV, 0 mV, and +35 mV; scale bars: 20 pA; 20 ms). c, Different cumulative probabilities of rise times for cells in the second (gray) and fourth (black) PN weeks (p < 0.001). The inset shows superimposed normalized averaged currents of two NG2 cells held at −70 mV at PN24 (black) and PN11 (gray) obtained with a single pulse stimulation in the presence of 10 μm NBQX and 50 μm d-AP-5. Stimulus artifacts were blanked for visibility; the time of stimulation is indicated with an arrowhead. d, Spontaneous slow rising currents of two NG2 cells held at −90 mV at PN21 (1) and PN22 (2) in the presence of 10 μm NBQX and 50 μm d-AP-5.