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. 2010 Jun 9;30(23):8012–8023. doi: 10.1523/JNEUROSCI.5749-09.2010

Figure 2.

Figure 2.

Indirect calorimetry measurements during nutrient intake monitoring in Trpm5 KO and WT mice. A, In agreement with the conditioning sessions, long-term (21 h) nutrient availability resulted in significantly higher levels of consumption of glucose versus serine solutions in both WT and KO animals (*p < 0.0009; see Results). B, Both WT and KO animals displayed higher respiratory quotients during glucose versus serine sessions (*p < 0.0003; see Results). However, WT mice displayed higher quotients during glucose sessions compared with KO mice (**p < 0.01; see Results). C, D, Mean respiratory quotient value across mice of time courses for WT (C) and KO (D) mice. Vertical dotted lines represent the time point at which nutrients became available for the first of the four cages. E, Both WT and KO animals displayed higher heat production during glucose versus serine sessions (*p < 0.0005; see Results). F, No nutrient- or genotype-specific effects were detected on ambulatory activity.