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Electrophysiological properties of pyramidal cells in WT and Celsr3|Dlx mice. A, Comparison of action potentials generated at a same level of injected current in both genotypes. B, Summary plot of discharge frequency as a function of stepwise injected current showing in the mutant cells, the decreased maximum frequency level, and the difference in the slope of the linear part of the current–frequency plot used as a measure of the intrinsic pyramidal cell excitability.
