Figure 1.

The SNCA region of interest. a, Schematic drawing of the 5′ region of SNCA with exons 1 and 2 (boxes) and the 5′ UTR and intron 1 (line). The arrow indicates the position of the putative core promoter; the triangle indicates the position of a rudimentary TATA box. Dimension of the CGI is depicted by the stripped box. Numbers are relative to the translation start site (ATG + 1). b, Fragments SNCA_{(−2079/−1507)} (promoter) and SNCA_{(−926/−483)} (intron) were used for bisulfite sequencing. c, Fragment SNCA_{(−1524/−189)} was used for reporter assays. d, Predicted transcription factor binding sites within SNCA_{(−926/−483)} (intron) adjacent to CpG dinucleotides.