Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Apr 14;30(15):5269–5282. doi: 10.1523/JNEUROSCI.4209-09.2010

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2010 the authors 0270-6474/10/305269-14$15.00/0

PMC Copyright notice

Figure 5. — Blockade of synaptic GABA_ARs does not enhance plasticity with 10 Hz stimulation. A, Selectively blocking synaptically expressed GABA_ARs with SR-95531 (5 μm) did not enhance synaptic potentiation in WT (n = 8) or α5 null mutant (Gabra5^−/−) (n = 8) slices. B, A summary of changes in synaptic responses after 10 Hz stimulation. These data represent the average of the last 5 min of recording for each slice in each group. C, The IPSP (black) was blocked with SR-95531 before (light blue) and after (red) 10 Hz stimulation, which indicates that synaptic GABA_ARs could not account for the differences in plasticity at this frequency. D, Average data showing the raw amplitudes of the IPSP at baseline (without SR-95531), with SR-95531, and after 10 Hz stimulation for WT (n = 6) and Gabra5^−/− (n = 6) cells. *p < 0.01.