BMAA-induced [Ca2+]i increase is sensitive to mGluR and TRPC channel blockers. A–C, Simultaneous recordings of currents (upper traces) and [Ca2+]i (lower traces) show pairs of BMAA responses in control solutions, following bath application of the drugs CPCCOEt (100 μm) (A), CNQX (10 μm) (B), SKF 96365 (100 μm) (C), and washout. Histograms show cumulative data of IBMAA and [Ca2+]i in the presence of the drugs CPCCOEt (A), CNQX (B), SKF 96365 (C), and washout normalized to the control response (white bar), measured in the same cell. *p < 0.05, **p < 0.01, #p < 0.0001.