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LTM is impaired in flies expressing human APP in the MBs. Flies were fed with RU for 48 h before spaced conditioning and for 24 h before performing memory tests. Performance indexes (PIs) calculated for female flies reveal that flies expressing APP in the adult MBs (MB-Sw/APP) display a memory score significantly different from that observed for the controls MB-Sw/+ and +/APP, respectively (ANOVA, *p = 0.0200, n = 6). Bars, mean ± SEM.
