Figure 3.

Emergence of perseverative behavior in Nogo-A^−/− mice. Discrimination reversal learning in the water T-maze. Performance is expressed as the percentage correct responses per day. Acquisition of the left–right discrimination learning was similar between the genotypes. A reversal effect was evident in both groups as suggested by the below-chance performance (represented by the dashed line) on the first day of the subsequent reversal training. However, Nogo-A^−/− mice displayed a clear deficit in reversal learning as evidenced by a significant genotype × day interaction (p < 0.05). All values are mean ± SEM. **p < 0.01, ***p < 0.001 based on post hoc pairwise comparisons. KO, Nogo-A^−/− (n = 16); WT, Nogo-A^+/+ (n = 16).