Table 1.
Alterations in brain monoamine levels and turnover in Nogo-A−/− mice
| DA | DOPAC | HVA | DOPAC/DA | HVA/DA | 5-HT | 5-HIAA | 5-HIAA/5-HT | |
|---|---|---|---|---|---|---|---|---|
| mPFC | ||||||||
| WT | 9.26 ± 1.58 | 1.01 ± 0.43 | 3.65 ± 1.53 | 0.11 ± 0.05 | 0.31 ± 0.12 | 73.95 ± 9.26 | 41.52 ± 6.77 | 0.59 ± 0.10 |
| KO | 6.50 ± 0.70 | 1.50 ± 0.29 | 4.69 ± 0.77 | 0.25 ± 0.05* | 0.75 ± 0.12* | 64.43 ± 6.28 | 56.48 ± 14.61 | 0.85 ± 0.18 |
| CPu | ||||||||
| WT | 1001.63 ± 124.89 | 63.29 ± 8.52 | 87.57 ± 13.93 | 0.06 ± 0.00 | 0.09 ± 0.00 | 64.89 ± 9.18 | 63.80 ± 9.57 | 1.03 ± 0.13 |
| KO | 378.72 ± 38.04*** | 28.76 ± 3.88** | 39.77 ± 4.81** | 0.08 ± 0.01 | 0.11 ± 0.02 | 16.55 ± 1.76*** | 6.29 ± 2.34*** | 0.42 ± 0.14** |
| NAc | ||||||||
| WT | 373.93 ± 50.33 | 45.58 ± 7.55 | 46.46 ± 7.55 | 0.12 ± 0.00 | 0.12 ± 0.01 | 174.83 ± 19.65 | 94.56 ± 9.53 | 0.60 ± 0.10 |
| KO | 322.99 ± 26.33 | 48.92 ± 5.56 | 47.22 ± 4.80 | 0.16 ± 0.02 | 0.15 ± 0.02 | 129.63 ± 9.40 | 64.80 ± 9.04 | 0.50 ± 0.11 |
| HPC | ||||||||
| WT | 6.43 ± 0.66 | ND | 2.55 ± 0.93 | ND | 0.41 ± 0.16 | 90.78 ± 7.94 | 102.09 ± 18.44 | 1.18 ± 0.23 |
| KO | 5.93 ± 0.69 | ND | 3.05 ± 1.11 | ND | 0.62 ± 0.31 | 66.15 ± 6.77* | 84.52 ± 15.12 | 1.90 ± 0.85 |
Levels are expressed as mean concentrations in nmol/mg protein. All values are mean ± SEM.
*p < 0.05, **p < 0.01, ***p < 0.001. mPFC, Medial prefrontal cortex; CPu, caudate-putamen; NAc, nucleus accumbens; HPC, hippocampus; ND, not detectable; KO, Nogo-A−/− (n = 6–9); WT, Nogo-A+/+ (n = 8–10).