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. 2010 Jan 20;30(3):885–893. doi: 10.1523/JNEUROSCI.3326-09.2010

Figure 4.

Figure 4.

In AD11 mice, EGABA is more positive than Vm. A, Cell-attached recordings of single NMDA channels obtained at two different pipette potentials in neurons from WT (open circles) and AD11 (filled circles) mice. B, Summary plot of single NMDA-mediated currents (INMDA) versus pipette potentials (Vp) in six WT (open circles) and five AD11 (filled circles) neurons. Currents through NMDA channels reversed at −75.3 mV in WT and at −76.2 mV in AD11. Assuming a reversal of NMDA currents equal to 0 mV, we estimated a mean resting membrane potential of −75 and −76 mV, respectively. C, Examples of cell-attached recordings of GABA-induced single-channel currents obtained at two different pipette potentials in neurons from WT (open circles) and AD11 (filled circles) mice. D, Summary plot of single GABA-mediated currents (IGABA) versus pipette potentials (Vp) in eight WT (open circles) and 10 AD11 (filled circles) neurons. In WT mice, current reversed at −76 mV and in AD11 at −56 mV.