Table 2.
Group differences in quantitative histology
| TLE+uMTS | TLE−MTS | p | pcorr | |
|---|---|---|---|---|
| Axonal density (axons/μm2) | 0.38 (0.04) | 0.44 (0.13) | 0.054 | 0.15 |
| Inner axonal diameter (din, μm) | 0.67 (0.07) | 0.72 (0.13) | 0.4 | 0.76 |
| Outer axonal diameter (dout, μm) | 1.04 (0.05) | 1.11 (0.14) | 0.27 | 0.59 |
| Myelin thickness (nm) | 186 (13) | 194 (25) | 0.53 | 0.88 |
| Cumulative axon membrane circumference (μm) | 164 (13) | 205 (39) | 0.035 | 0.1 |
| Myelin fraction | 0.12 (0.01) | 0.15 (0.02) | 0.012 | 0.03 |
| Extra-axonal fraction | 0.79 (0.02) | 0.72 (0.03) | 0.004 | 0.01 |
| Intra-axonal fraction | 0.09 (0.02) | 0.13 (0.03) | 0.07 | 0.19 |
Mean electron microscopy blinded measurements per group are taken from the average features over 10 stereology frames per subject. Numbers in parentheses represent SEM.