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Survival of GIFN mice is reduced in the absence of STAT1 or IRF9. Survival was significantly longer in GIFNxIRF9 KO mice compared with GIFNxSTAT1 KO mice (p < 0.0001, χ2 logrank test). While IFNGR-null GIFNxIRF9 KO mice were not viable (*), IFNGR-haploinsufficiency resulted in a significantly shorter survival of these animals compared with GIFNxIRF9 KO mice (p < 0.0001, χ2 logrank test).
