Table 3.
Increased synchronization with the posterior DMN
| Cluster | Volume (mm3) | Mean (SD) APOE ϵ4− | Mean (SD) APOE ϵ4+ | Cohen's d | (x, y, z) max |
|---|---|---|---|---|---|
| HI/AM analysis p ≤ 0.05 | |||||
| R HI/AM | 4608 | 0.03 (2.86) | 4.83 (4.70) | 1.23 | (16, 30, 12) |
| L HI/CWM | 832 | 1.49 (5.67) | 6.83 (6.43) | 0.88 | (26, 21, 20) |
| L AM/parahippocampal gyrus | 64 | −1.48 (8.56) | 5.69 (9.05) | 0.81 | (31, 32, 14) |
| FB analysis p ≤ 0.05 | |||||
| R insular/temporal pole | 19,328 | 0.42 (3.09) | 6.27 (5.90) | 1.24 | (13, 33, 14) |
| R supramarginal/postcentral | 9152 | 0.89 (4.79) | 7.59 (8.29) | 0.99 | (8, 26, 27) |
| L crus/vermis II | 5120 | −2.32 (7.09) | 8.64 (12.6) | 1.07 | (23, 12, 10) |
| R lateral occipital/cuneal | 2816 | 0.97 (3.26) | 5.39 (5.24) | 1.01 | (17, 11, 23) |
| R precentral gyrus | 2304 | −2.52 (6.78) | 3.81 (6.97) | 0.92 | (12, 32, 25) |
| R caudate/CWM | 512 | −1.52 (4.68) | 3.11 (6.42) | 0.83 | (18, 32, 24) |
| R superior frontal/paracingulate gyrus | 192 | −5.43 (8.26) | 2.53 (7.93) | 0.98 | (21, 36, 31) |
| R CWM | 128 | −1.53 (3.89) | 1.56 (4.78) | 0.71 | (15, 32, 24) |
| R occipital fusiform/lingual gyrus | 64 | 0.88 (5.05) | 4.08 (5.24) | 0.62 | (18, 11, 16) |
Significant clusters from the spatially restricted [hippocampus/amygdala (HI/AM)] and full-brain (FB) analysis, with respective cluster volumes, mean synchronization for carriers and noncarriers, Cohen's d (effect of APOE genotype), and MNI coordinates of peak voxel within each cluster. The anatomical notation corresponds to the coordinate for the peak voxel according to the Harvard–Oxford cortical and subcortical atlas. For the cluster with (x, y, z) max = (23, 12, 10) in the FB analysis, the cerebellar atlas in MNI-152 space after normalization with FNIRT was used. Cohen's d was computed as (mean carrier − mean noncarrier)/SD pooled. CWM, Cortical white matter.