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. 2019 Aug;25(8):905–920. doi: 10.1261/rna.069534.118

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© 2019 Lorenzini et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 2. — Experimental procedure to investigate the role of human PRPF40B in the regulation of AS and of two MDS mutations. (A) Number of DEGs upon KO (K562 vs. KO), in rescue WT cells (KO vs. WT) and those in common between the two comparisons which are under control of PRPF40B (DEGs Rescued) (fc ≤ 0.3, fc ≤ −0.3, P-value ≤ 0.05). (B) Number of DEGs regulated by PRPF40B (DEGs Rescued) which are rescued (blue) or not (red) by the MDS mutations. (C) Gene ontology of the DEGs regulated by PRPF40B shows the genes are mainly involved in cholesterol biogenesis, glycolysis, and hypoxia.