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. 2019 Aug;25(8):948–962. doi: 10.1261/rna.070417.119

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© 2019 Nasef et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 6. — Target RNA cleavage inhibits cOA synthesis. (A) Two models for control of cOA synthesis are shown. In Model 1, Cas10-Csm is active in cOA synthesis only when bound to an intact target RNA. In Model 2, Cas10-Csm bound to target RNA is active in cOA synthesis regardless of whether the RNA is cleaved or not. (B) A mathematical model built from the rates in A predicts the fraction of Cas10-Csm active in cOA synthesis as a function of time in each model. (C) An experimental, wt cOA progress curve and a Cas10-Csm^Csm3D32A, experimental cOA progress curve are compared to the model curves for 0–1 min. (D) Experimental and model progress curves are shown from 0 to 60 min.