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. 2019 Aug;25(8):1020–1037. doi: 10.1261/rna.070649.119

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© 2019 Talkish et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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FIGURE 4. — Conserved interfaces revealed by Tat-SF1–ULM structures. (A) Hsh155 ULM (orange) bound to Tat-SF1 UHM (blue). The K104 side chain (parentheses) is disordered and lacks interpretable electron density. (B) Model of Hsh155 bound to Cus2 UHM. Interacting residues that differ from the Tat-SF1 homolog were substituted with a sterically compatible rotamer (cyan). Residues modified by mutagenesis (Cus2 D204 and F253; Hsh155 R100 and W101) are marked by asterisks. (C) Comparison of human SF3b1 ULM bound to Tat-SF1 UHM (PDB ID 6N3E).