Figure 8.

Model of interaction between the medial and lateral callosal axons. The repulsive effects between the medial and lateral cortical axons contribute to the axonal segregation in the CC. Under normal conditions, lateral cortical axons would use the interaction with medial cortical axons to project to the contralateral neurons in the lateral cortex through the CC. When the functions of EphA3 are inhibited, the lateral cortical axons cannot interact with the medial cortical axons, disrupting their correct pathfinding and/or proper extension.