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. 2011 Nov 9;31(45):16327–16335. doi: 10.1523/JNEUROSCI.3611-11.2011

Figure 4.

Figure 4.

Long-term effects of CX3CL1 on ischemic brain. a, Study paradigm. b, Results of Bederson's (top), De Ryck's (middle), and foot-fault (bottom) tests in vehicle-treated (black circles) and CX3CL1-treated (white circles) rats at different days after pMCAO (n = 11). In the foot-fault test, values for sham-operated rats were similar to those obtained at 24 h. c, Results of structural MRI data analysis of brain lesions in ischemic rats treated with CX3CL1 and saline, 50 d after pMCAO. Volumes of cortex for ipsilateral (I) and contralateral (C) hemispheres and total lesion volume are shown for vehicle- and CX3CL1-treated rats. Representative images of ischemic brains are shown for vehicle- and CX3CL1-treated rats. d, DTI data analysis showing ADC of the ipsilateral and contralateral hemisphere of CX3CL1- and vehicle-treated rats in cortex and external capsula. Representative ADC images are shown. All data are mean ± SE from six rats for each experimental condition. Two-way ANOVA followed by the Bonferroni's post hoc test: *p < 0.05, **p < 0.01, ***p < 0.001.