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Effects of Aβ1–42 on DBB WCC in wt mice. A, Aβ1–42 (1 μm) significantly depresses WCC (*p < 0.05, n = 8 at +30 mV), inset shows the voltage ramp protocol applied for 10 s. B, Reversed oligomers Aβ42–1 (1 μm) peptide had no effect on WCC (p = 0.36 n = 6 at +30 mV). C, Dose–response relationship for Aβ1–42-evoked inhibition of peak WCC at +30 mV (n = 5 at each dose).
