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. 2011 Nov 16;31(46):16792–16807. doi: 10.1523/JNEUROSCI.3109-11.2011

Figure 9.

Figure 9.

Effect of HES1 on Otx2 expression in vivo. A, Structure of Crx 2kb-promoter-directed LacZ construct. B–D, Immunostaining for OTX2 (B) and LacZ (C). (D), Merge of (B) and (C). The presumptive photoreceptor layer lies between the RPE and NBL. Scale bar, 100 μm. E, Percentage of OTX2-positive or -negative cells in LacZ-positive cells. Data are means ± SEM. n = 199 cells on 12 sections of 3 retinas from 3 animals were analyzed. F, Structure of Crx 2 kb-promoter-directed FLAG-Hes1 construct. G–I, Immunostaining for OTX2 (G) and FLAG-HES1 (H). (I), Merge of (G) and (H). Scale bar, 100 μm. J, Percentage of OTX2-positive or -negative cells in FLAG-HES1-positive cells. Data are means ± SEM. n = 298 cells on 4 sections of 3 retinas from 3 animals were analyzed.