Figure 2.

Lack of Mkk7 causes abnormal brain development and reduced axon tracts in the cerebrum. A, Gross appearance of whole brains of control and Mkk7^flox/flox Nestin-Cre embryos at E18.5. Results are representative of embryos examined per genotype. Scale bar, 1 mm. B–D, Histological analysis of brain defects in Mkk7^flox/flox Nestin-Cre mice. Horizontal sections of the brains of control and Mkk7^flox/flox Nestin-Cre embryos at E18.5 were stained with cresyl violet. Left, Forebrains with inset boxes indicating CC (B), AC (C), and IC (D) are shown. Scale bar, 500 μm. Right, Inset boxes in left panels are magnified. Scale bar, 500 μm.