Skip to main content
. 2011 Nov 16;31(46):16731–16747. doi: 10.1523/JNEUROSCI.4273-11.2011

Figure 3.

Figure 3.

Morphological and electrophysiological features in stage 3–5 small axonless versus multipolar neurons. A, Morphological reconstructions of postnatally generated small axonless neurons and multipolar neurons at the indicated stages. B, Representative voltage-clamp recordings from the neurons shown in A demonstrating the development of spontaneous activity in stage 3–5 cells. C, In both cell classes at stage 3, only GABAergic PSCs (red traces) could be recorded. From stage 4 onwards, glutamatergic PSCs (blue traces) were also present. Small axonless neurons, red traces: mean of 5 (stage 3), 10 (stage 4) and 68 (stage 5) GABAergic PSCs; blue traces: mean of 9 (stage 4) and 14 (stage 5) glutamatergic PSCs. Multipolar neurons, red traces: mean of 5, 10 and 43 GABAergic PSCs; blue traces: mean of 9 and 34 glutamatergic PSCs. Decay times are indicated above each trace. D, Current-clamp recordings show the gradual increase in spiking activity in response to 1 s depolarizing steps. Note that small axonless neurons never fire more than a single action potential in response to a sustained depolarization, even at their most advanced stage of maturation.