Table 1.

The group analysis for the repetitive painful thermal stimulation showed a significant activation in brain regions associated with pain processing in both groups (p < 0.001, FWE corrected)

Anatomical location	MNI			p	Peak t scores
	x	y	z
R superior temporal gyrus	54	0	3	<0.001	14.09
R operculum	39	−18	18	<0.001	12.73
R insular cortex	39	6	9	<0.001	12.15
L superior temporal gyrus	−60	3	0	<0.001	11.10
L insular cortex	−36	6	9	<0.001	10.73
L anterior insular cortex	−27	27	6	<0.001	10.20
R midcingulate cortex	6	12	42	<0.001	9.61
L cerebellum (VIII)	−18	−69	−51	<0.001	7.03
R cerebellum (crus1)	30	−78	−27	<0.001	8.28
R DLPFC	39	48	30	<0.001	6.95
R brainstem	18	−36	−51	<0.001	6.79
L inferior frontal gyrus	−27	30	−15	<0.001	6.71
L nucleus caudatus	−6	6	3	<0.001	8.48

This finding was observed for all imaging sessions (days 1, 8, and 90). The changes are tabulated in terms of the brain region and the corresponding Brodmann's area (BA). The x, y, z coordinates are according to the MNI atlas. Each location is the peak within a cluster (defined as the voxel with the highest Z score).