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. 2010 Aug 25;30(34):11317–11325. doi: 10.1523/JNEUROSCI.1491-10.2010

Figure 5.

Figure 5.

Behavioral alterations are similar in wild-type and NOX2-deficient mice after amphetamine exposure. Thirty minutes after injection with amphetamine (1 mg/kg, i.p.) or saline, mice were placed in the arena for open-field test. A–D, Bar graphs represent the frequency of groomings (A), rearings (B), crossings (C), and sniffings (D) recorded during the 20 min of the test in WT and KO NOX2 mice. For groomings: Ftr×gen(1,11) = 2.299, p = 0.147; Ftr(1,11) = 415.537, p < 0.001; Fgen(1,11) = 1.123, p = 0.312. ***p < 0.001 WT saline versus WT amphetamine and KO NOX2 saline versus KO NOX2 amphetamine; NS: WT saline versus KO NOX2 saline, p = 0.837; WT amphetamine versus KO NOX2 amphetamine, p = 1.000. For rearings: Ftr×gen(1,11) = 0.363, p = 0.703; Ftr(1,11) = 21.464, p < 0.001; Fgen(1,11) = 0.0546, p = 0.819; **p < 0.01 WT saline versus WT amphetamine; *p < 0.05 KO NOX2 saline versus KO NOX2 amphetamine; NS: WT saline versus KO NOX2 saline, p = 0.485; WT amphetamine versus KO NOX2 amphetamine, p = 0.862. For crossings: Ftr×gen(1,11) = 0.00361, p = 0.996; Ftr(1,11) = 13.164, p = 0.001; Fgen(1,11) = 0.114, p < 0.741; **p < 0.01 WT saline versus WT amphetamine; *p < 0.05 KO NOX2 saline versus KO NOX2 amphetamine; NS: WT saline versus KO NOX2 saline, p = 0.796; WT amphetamine versus KO NOX2 amphetamine, p = 0.854. For sniffings: Ftr×gen(1,11) = 1.028, p = 0.327; Ftr(1,11) = 20.887, p < 0.001; Fgen(1,11) = 0.785, p = 0.390 NS: WT saline versus KO NOX2 saline, p = 0.927; KO NOX2 saline versus KO NOX2 ketamine, p = 0.211. ***p < 0.001; **p < 0.01; *p < 0.05 using two-way ANOVA followed by Tukey's post hoc test (n = 5 WT saline; n = 5 WT amphetamine; n = 4 KO NOX2 saline; n = 5 KO NOX2 amphetamine).