A2A receptors regulate post-tetanic potentiation. A, The presence of the A2A receptor antagonist, SCH, prevented post-tetanic potentiation induced by single photolysis of NP-EGTA in PSCs. B, No post-tetanic potentiation was elicited with the single photolysis protocol at NMJs of A2A −/− animals. C, Post-tetanic potentiation was occluded by prior addition of the A2A agonist CGS21680. D, Addition of the A1 receptor antagonist PSB-36 had no effect on post-tetanic potentiation. E, Post-tetanic potentiation was induced by the single photolysis protocol at NMJs from A1 −/− mice. pre, Before; post, after.