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. 2010 Sep 15;30(37):12535–12544. doi: 10.1523/JNEUROSCI.1920-10.2010

Figure 1.

Figure 1.

Lysosomal depletion and AP accumulation in MPTP-intoxicated mice. A, LC3II immunoblot levels in ventral midbrain protein homogenates from saline- and MPTP-injected mice. B, Immunoblot Lamp1 levels in ventral midbrain protein homogenates from saline- and MPTP-injected mice at day 1 post-MPTP. C, Double immunofluorescence with Lamp1 (green) and TH (red) in ventral midbrain sections of saline- and MPTP-injected mice at day 1 post-MPTP. D, β-Hexoaminidase enzymatic activity in ventral midbrain lysosomal-enriched fractions (fractions 5, 6, and 7) from saline- and MPTP-injected mice at day 0 and day 1 post-MPTP. In all experiments, n = 5–7 animals per experimental group. *p < 0.05 compared with saline-injected mice. In C, white dotted line delimits SNpc. Scale bar, 10 μm.