Figure 5.

Microtubule fragmentation in G2019S- and Tau-expressing dendrites. A–G, Low-order trunks of class IV ddaC neurons visualized by ppk-GAL4-driven mCD8GFP (A), or also carrying transgenes Tau-GFP (B), wild-type LRRK2 (C), G2019S (D), G2019S-K1906M (E), G2019S + Tau-GFP (F), or Tau-GFP in an e03680/+ background (G). Third-instar larvae were dissected and stained for the microtubule-associated protein Futsch (left panels) and GFP (merged in right panels). Arrowheads in B, D, and F indicate dendrites with discontinuous Futsch expression, and asterisks in F mark dendrites containing nearly no Futsch signals. Scale bar: (in A) A–G, 15 μm.