Table 3.

Regions demonstrating significant reductions in gray matter volume in schizophrenia

Contrast and region	Volume (mm3)a	Peak MNI coordinate			Z
		x	y	z
Controls > patients
Insula	29,500	−38	8	−11	5.20
Insula	—	−38	8	−2	5.04
Inferior frontal gyrus (opercular)	—	−48	8	25	4.85
Anterior cingulate gyrus	12,314	−31	−95	7	4.34
Middle occipital gyrus	2,736	55	33	15	4.29
Middle occipital gyrus	3,065	57	23	20	4.19
Inferior frontal gyrus (triangular)	1,315	52	39	−5	4.12
Inferior frontal gyrus (triangular)	—	37	21	0	3.64
Inferior frontal gyrus (opercular)	—	39	14	−9	3.59
Insula	1,606	43	6	1	4.12
Insula	—	−24	8	56	4.05
Insula	—	−33	10	57	3.81
Middle frontal gyrus	1,265	−29	0	61	3.91
Middle frontal gyrus	—	−38	8	−11	3.77
Precentral gyrus	—	−38	8	−2	3.41

^aNumber of contiguous active voxels × 1 mm³ (1 × 1 × 1). See Table 2 footnote.