Table 1.
Density of neurons in motor nerve nuclei and spinal cord
| Nucleus | Control (n = 3) neurons/mm3 | AR2 (n = 4) neurons/mm3 |
|---|---|---|
| III | 11,253 ± 1783 | 10,441 ± 632 |
| IV | 15,783 ± 1694 | 16,032 ± 658 |
| VI | 10,117 ± 996 | 10,699 ± 195 |
| Vm | 8809 ± 417 | 8623 ± 246 |
| Vm (>25 μm) | 3603 ± 213 | 2767 ± 175** |
| VII | 1041 ± 124 | 1016 ± 96 |
| VII (>20 μm) | 91.1 ± 32.7 | 67.7 ± 13.1** |
| X | 11,442 ± 1932 | 11,652 ± 2387 |
| XII | 11,800 ± 541 | 9834 ± 1530 |
| XII (>20 μm) | 832.7 ± 92.9 | 677.8 ± 116.2** |
| C5 AH (≤20 μm) | 37,147 ± 326 | 37,941 ± 331 |
| C5 AH (>20 μm) | 25.5 ± 0.9a | 13.7 ± 0.7a,** |
| L5 AH (>20 μm) | 29.3 ± 0.32a | 15.9 ± 0.31a,** |
| DH | 476,312 ± 12,623 | 498,816 ± 21,446 |
| VR | 840.0 ± 26.5b | 626.3 ± 31.4b,* |
Numbers are the neuronal density per cubic millimeter (mean ± SEM) in each nucleus from mice at 12 months of age. For Vm, VII, and XII, neurons with large diameter (>20 or 25 μm) were also counted. AR2, ADAR2flox/flox/VAChT–Cre.Fast mice; III, nucleus of oculomotor nerve; IV, nucleus of trochlear nerve; VI, nucleus of abducens nerve; Vm, motor nucleus of trigeminal nerve; VII, nucleus of facial nerve; X, dorsal nucleus of the vagus nerve; XII, nucleus of hypoglossal nerve; C5 AH, anterior horn of the fifth cervical cord; L5 AH, anterior horn of the fifth lumbar cord; DH, zona gelatinosa of the spinal cord; VR, ventral roots (L5).
*p < 0.005;
**p < 0.001 (ANOVA).
aNumber of neurons per section.
bNumber of axons.