Table 1.
Summary of the noir phenotype
| 5 dpf | 6 dpf | 7 dpf | |
|---|---|---|---|
| External appearance | nir darker than siblings | nir darker than siblings | nir darker than siblings |
| Retinal morphology | wt-like | Cholinergic amacrine cells reduced | Multiple cell types reduced (PRCs, ACs, MCs, BPCs) |
| ERG | a-wave reduced | a-wave more reduced | a-wave lost |
| b-wave reduced | b-wave lost | b-wave lost | |
| d-wave reduced | d-wave more reduced | d-wave lost | |
| OKR | No OKR | No OKR | No OKR |
| VMR | wt-like | wt-like | Slower responses |
| Phototaxis | wt-like | No phototaxis | No phototaxis |
| Locomotion | Locomotion reduced | Locomotion more reduced | Almost no locomotion |
Abbreviations: wt, Wild type; PRC, photoreceptor; AC, amacrine cell; MC, Müller glia cell; BPC, bipolar cell.