Figure 1.

Absence of ADAM8 aggravates the wobbler (WR) disease. A, Kaplan–Meier survival curves of wr/+ Adam8 ^+/+ (black line; n = 45), wr/+ Adam8 ^−/− (dashed black line; n = 34), wr/wr Adam8 ^+/− (gray line; n = 32), and wr/wr Adam8 ^−/− (dashed gray line; n = 38) mice for 54 d after birth. Significance was calculated by pairwise log rank tests for survival with p < 0.07. B, Grip strengths of forelimbs of wr/+ Adam8 ^+/+ (squares), wr/+ Adam8 ^−/− (circles), wr/wr Adam8 ^+/− (rhombs), and wr/wr Adam8 ^−/− (triangles) mice. For all genotypes, n = 15. Mean ± SD values. Note the total loss of force within 24 d after birth in wr/wr Adam8 ^−/− individuals, leading to complete akinesis and premature death. p.n., Postnatal.