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. 2010 Sep 22;30(38):12806–12815. doi: 10.1523/JNEUROSCI.3142-10.2010

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Copyright © 2010 the authors 0270-6474/10/3012806-10$15.00/0

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Figure 4. — Reduced nociceptor GRK2 only affects hyperalgesia induced by an EP4 agonist. A, Percentage decrease in heat-withdrawal latency times after intraplantar sulprostrone (EP1/3 agonist) injection in SNS–GRK2 ^+/+ (WT) and SNS–GRK2 ^+/− mice (n = 8 per genotype). B, Percentage decrease in heat-withdrawal latency time after intraplantar L-902668 (EP4 agonist) injection in SNS–GRK2 ^+/+ control animals and in SNS–GRK2 ^+/− (n = 8 per genotype). Data are expressed as mean ± SEM. **p < 0.01, ***p < 0.001.