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. 2010 Sep 22;30(38):12632–12641. doi: 10.1523/JNEUROSCI.1264-10.2010

Figure 6.

Figure 6.

Effects of rapamycin infusions into the NAc core on NMDA-induced increases in reinstatement of cocaine seeking and NMDA-induced increases in p70s6k–rps6 phosphorylation. a, b, Percentage (mean ± SEM) of phosphorylated p70s6k (a) and rps6 (b) in the NAc core after infusions of rapamycin, NMDA, and their vehicles into the NAc core. Data are expressed as a percentage of the values obtained for rats infused with vehicle. c, Number of responses (mean ± SEM) on the active nose-poke operandum after combined infusions of NMDA (250 ng/side), rapamycin (50 μg/side), or their vehicles into the NAc core 5 or 30 min before the reinstatement tests that were conducted after extinction. Rapamycin infusions into the NAc core reversed NMDA-induced potentiation of cocaine seeking and NMDA-induced p70s6k and rps6 phosphorylation. *p < 0.05, different from vehicle–NMDA group. #p < 0.05, different from vehicle–vehicle group (n = 8–10 per group). Veh, Vehicle (sterile saline for NMDA; DMSO for rapamycin); Rapa, rapamycin.