Figure 7.

Infusion of rapamycin into the NAc core did not alter cocaine intake during cocaine self-administration training. Number of cocaine infusions (0.75 mg/kg per infusion) during the 3 h training session (mean ± SEM) before and after bilateral infusions of rapamycin (50 μg/side) or its vehicle (20% DMSO) into the NAc core on the test day after 10 d of cocaine self-administration training. Baseline cocaine intake is expressed as the number of cocaine infusions from day 8 to day 10. Rats demonstrated reliable cocaine self-administration during baseline. No difference in cocaine intake was observed between baseline and the test days in any of the groups (n = 7–10 per group).