Figure 9.
Bidirectional hippocampal synaptic plasticity in quinone reductase 2 knock-out mice (QR2−/−). A, Long-term potentiation was induced by HFS (100 Hz, 100 pulses). No difference between WT (n = 11) and QR2−/− (n = 9) mice was found. B, Long-term depression (induced by LFS: 1 Hz, 900 pulses) was examined in both young (top) and adult (bottom) WT (n = 5) and QR2−/− (n = 5) mice. We observed no changes in LTD between these two types of mouse in both age groups.