Figure 2.

Oscillatory responses mediated by direct GABAergic input in pyramidal cells. A, Top, No clear oscillatory depolarizing responses were detected in pyramidal cells recorded in the low intracellular Cl⁻ condition (PC_lowCl) during the prototypic afterdischarge in the field potential (arrowhead). Bottom, The oscillatory responses in the prototypic afterdischarge (arrowhead) observed in pyramidal cells recorded in the high intracellular Cl⁻ condition (PC_highCl). The oscillatory responses appeared to depend on Cl⁻ conductance. B, Left, Voltage-clamp recordings of the oscillatory responses in the prototypic afterdischarge (arrowhead) and exogenous GABA responses (triangles, 2, 7, 12, and 17 s after HFS) in a pyramidal cell. Right, Similar reversal potentials of oscillatory responses (filled circles) and exogenous GABA responses (gray triangles) in the same pyramidal cell. These reversal potentials may be artificially low because of the low-Cl⁻-based electrode solution.