Figure 6.
The prototypic afterdischarge mediated through GABAA receptors and gap junctions among interneurons. A, Abolishment of the prototypic afterdischarge in an FS interneuron by the application of 25 μm bicuculline. Calibrations are the same in A, B, and D. B, Abolishment of the prototypic afterdischarge in a basket cell by 100 μm carbenoxolone. C, Summary of the effects of bicuculline and carbenoxolone on the prototypic afterdischarge in interneurons. D, Spontaneous (green boxes) and evoked (red boxes) postsynaptic potentials around the prototypic afterdischarge expression (arrowhead) in another basket cell. Note that spontaneous hyperpolarizing postsynaptic potentials appeared only in the resting state (top, left and right) and that single shocks of electrical stimulation (dots) evoked excitatory (bottom left), depolarizing (bottom middle), and hyperpolarizing (bottom right) responses. E, Excitatory (spike-evoking) oscillatory responses during the prototypic afterdischarge in an interneuron recorded with the gramicidin-perforated patch-clamp method (INgpp). F, Excitatory/depolarizing responses to external GABA application (triangles) after HFS in the gramicidin-perforated patch-clamp condition.