Table 2.

Regional brain activation

Region		x	y	z	Z
Regional brain activation during task 1 (active regulation)
Negative > neutral
Healthy control subjects
Amygdala	R	24	−4	−16	4.26†
	L	−24	−4	−22	4.88
Ventral striatum	R	8	0	−2	6.87
Dorsomedial prefrontal cortex	L	−6	54	24	6.83
Ventrolateral prefrontal cortex	L	−42	22	−20	6.59
Fusiform gyrus	R	45	−56	−20	5.73
	L	−42	−50	−22	5.87
MDD patients
Amygdala	R	24	0	−22	5.30
	L	−20	−4	−20	4.87
Dorsomedial prefrontal cortex		0	60	22	6.82
Ventrolateral prefrontal cortex	R	28	20	−24	6.51
	L	−36	22	−20	5.58
Dorsolateral prefrontal cortex	R	58	26	28	6.39
Fusiform gyrus	R	44	−56	−20	7.62
	L	−40	−60	−16	8.00
Regulation > no regulation
Healthy control subjects
Dorsolateral prefrontal cortex	R	40	26	46	5.85
		42	44	24	5.79
Inferior parietal cortex	R	60	−56	38	7.40
MDD patients
Inferior parietal cortex	R	62	−48	32	6.45
	L	−58	−36	40	5.67
No regulation negative > neutral
Healthy controls
Amygdala	R	24	−4	−16	3.69†
	L	−22	−4	−22	3.27†
Dorsomedial prefrontal cortex		4	38	56	4.77
Dorsolateral prefrontal cortex	R	54	22	30	4.80
Fusiform gyrus	R	48	−72	−18	5.18
	L	−38	−60	−14	4.80
MDD patients
Amygdala	R	24	−2	−22	3.98†
	L	−30	−4	−16	3.89†
Dorsomedial prefrontal cortex		0	54	32	4.83
Dorsolateral prefrontal cortex	R	56	24	30	5.35
Fusiform gyrus	R	40	−66	−18	6.26
	L	−40	−60	−16	6.21
Negative no regulation > regulation
Healthy control subjects
Amygdala	R	24	−4	−16	4.46†
	L	−24	−8	−16	3.99†
Ventral striatum	R	8	0	−4	5.25
Hippocampus	R	24	−22	−14	5.90
	L	20	−36	−12	5.33
Lingual gyrus	R	2	−90	−6	7.73
	L	−6	−94	−6	7.73
MDD patients
Amygdala	R	22	−6	−14	3.37†
	L	−22	−8	−16	3.21†
Hippocampus	R	16	−28	−12	5.03
Lingual gyrus	R	28	−94	−2	6.13
	L	−20	−98	0	6.08
Negative regulation > no regulation
Healthy control subjects
Dorsolateral prefrontal cortex	R	42	44	24	5.15
		42	32	40	5.08
		26	6	52	4.79
Inferior parietal cortex	R	60	−46	30	6.93
MDD patients
Inferior parietal cortex	R	62	−48	30	5.53
	L	−60	−36	38	5.31
Healthy control subjects > MDD patients
Dorsolateral prefrontal cortex	R	36	44	28	3.55†
Negative > Neutral (Regulation > No Regulation)
Healthy control subjects
Inferior parietal/superior temporal cortex	R	48	−62	16	5.75
	L	−54	−60	16	5.22
MDD patients
Inferior parietal/superior temporal cortex	R	52	−60	12	5.65
Regional brain activation during task 2 (passive viewing)
Negative > neutral
Healthy control subjects
Amygdala	R	20	0	−24	4.71
	L	−20	−2	−26	2.97†
MDD patients
Amygdala	R	20	−4	−16	3.06†
	L	−26	−2	−20	4.14†
Inferior frontal gyrus	L	−58	16	14	4.92
Fusiform gyrus	R	48	−48	−26	6.20
	L	−44	−68	−20	6.77
Negative no regulation > regulation
Healthy control subjects
Amygdala	L	−22	−4	−22	3.88†
	R	22	2	−20	3.47†
Healthy control subjects > MDD patients
Amygdala	R	22	2	−20	3.26†
	L	−18	−6	−18	2.85†
Negative > neutral (regulation > no regulation)
Healthy control subjects
Amygdala	R	24	0	−14	3.61†
	L	−24	−6	−14	3.19†
Healthy control subjects > MDD patients
Amygdala	R	22	−2	−20	3.24†
	L	−22	−6	−20	3.01†

R, Right; L, left; x, y, z, respective MNI coordinates of peak voxel activation; Z, Z value; all results p < 0.05 family-wise error corrected for multiple comparisons across whole brain;

^†p < 0.05 family-wise error corrected for anatomical a priori ROI.