Skip to main content
. 2010 Nov 24;30(47):15981–15986. doi: 10.1523/JNEUROSCI.1872-10.2010

Figure 3.

Figure 3.

Injection of TAT-pep-R845A peptide into LA immediately after training, 30 min before test, or 24 h post-training has no effect on long-term fear conditioning memory formation, retrieval, or maintenance. A, Rats were injected into LA with TAT-pep-R845A (n = 6) or TAT (n = 5) peptides (50 μg/μl), 0.5 μl per LA) immediately after fear conditioning training and tested for fear memory formation 24 h later. Rats microinjected with TAT-pep-R845A were not significantly different in long-term fear memory from TAT-injected rats (p > 0.1). B, TAT-pep-R845A (n = 5) or TAT (n = 5) peptides (50 μg/μl, 0.5 μl per LA) were injected into LA 30 min before fear conditioning memory test. There was no significant effect of the TAT-pep-R845A peptide when compared with the TAT peptide (p > 0.3). C, TAT-pep-R845A (n = 3) or TAT (n = 4) peptides (50 μg/μl, 0.5 μl per LA) were injected into LA 24 h after fear conditioning training. The animals were tested 48 h afterward. There was no significant effect of the TAT-pep-R845A peptide when compared with the TAT peptide (p > 0.4).