Table 3.
Differences in Opioid Associations in Diabetic vs Idiopathic Gastroparesis
| Variable | Diabetic gastroparesis |
Idiopathic gastroparesis |
P value, diabetic vs idiopathic | ||||
|---|---|---|---|---|---|---|---|
| On opioids | Not on opioids | P value | On opioids | Not on opioids | P value | ||
| 4-hour scintigraphic gastric retention, means ± SD | 40% ± 25% | 41% ± 25% | .81 | 34% ± 20% | 27% ± 16% | .91 | .008 |
| Symptoms | |||||||
| Overall GCSI score | 3.1 ± 1.0 | 2.8 ± 1.1 | .02 | 3.2 ± 1.1 | 2.8 ± 1.0 | .002 | .91 |
| Nausea/vomiting subscore | 3.0 ± 1.4 | 2.5 ± 1.5 | .01 | 2.6 ± 1.5 | 2.1 ± 1.3 | .001 | .96 |
| Bloating/distention subscore | 3.1 ± 1.5 | 2.7 ± 1.7 | .07 | 3.3 ± 1.4 | 3.0 ± 1.6 | .01 | .95 |
| Upper abdominal pain score | 3.3 ± 1.7 | 2.6 ± 1.7 | .002 | 3.4 ± 1.5 | 2.8 ± 1.7 | <.0001 | .93 |
| Lower abdominal pain score | 2.2 ± 1.6 | 2.0 ± 1.7 | .41 | 2.6 ± 1.6 | 1.8 ± 1.5 | <.0001 | .02 |
| Constipation score | 2.7 ± 1.7 | 2.3 ± 1.7 | .12 | 2.7 ± 1.9 | 2.4 ± 1.7 | .19 | .63 |
| PAGI-QOL, means ± SD | 2.2 ± 1.2 | 2.9 ± 1.2 | .0003 | 2.3 ± 1.0 | 2.6 ± 1.1 | .006 | .31 |
| Hospitalized for gastroparesis in past year | 59/91 (65%) | 54/109 (50%) | .03 | 72/149 (48%) | 69/234 (29%) | .0002 | .65 |
| Hospitalizations per year, means ± SD | 5.3 ± 7.3 | 2.8 ± 6.3 | .01 | 2.1 ± 3.6 | 0.9 ± 2.5 | .0005 | .09 |
| Medication use | |||||||
| Antiemetics | 70/91 (77%) | 53/109 (49%) | <.0001 | 103/149 (69%) | 119/234 (51%) | .0004 | .18 |
| Nonopiate analgesics | 48/91 (53%) | 62/109 (57%) | .56 | 97/149 (65%) | 142/234 (61%) | .38 | .29 |
| Pain modulators | 48/91 (53%) | 30/109 (30%) | .0003 | 53/149 (36%) | 47/234 (20%) | .0008 | .44 |
| Laxatives | 13/27 (48%) | 12/40 (30%) | .02 | 23/48 (48%) | 39/100 (39%) | .28 | .55 |
GCSI, Gastroparesis Cardinal Symptom Index; PAGI-QOL, Patient Assessment of Upper Gastrointestinal Disorders Quality of Life.