Table 6.
Summary of histopathology findings.
| Dose group (mg/kg bw/day) | Control | 400 | 800 | 1200 | |
|---|---|---|---|---|---|
| Organs | Observations | n=10 | N/A | N/A | n=10 |
| Male | |||||
| Animals with no microscopic findings | 7/10 | N/A | N/A | 6/10 | |
| Kidneys: | Pelvic dilatation, slight | 2/10a,b | 2/2 | 2/2 | 2/10 |
| Liver: | Focal interstitial fibrosis, mild | 1/10a | / | / | 0/10 |
| Lungs: | Acute pulmonary hemorrhage, mild | 0/10 | / | / | 1/10c |
| Alveolar emphysema, minimal | 1/10 | / | / | 1/10d | |
| Hyperplasia of BALT, minimal to mild | 1/10b | / | / | 1/10d | |
| Thymus: | Acute hemorrhage, mild | 0/10 | / | / | 1/10c |
|
| |||||
| Female | |||||
| Animals with no microscopic findings | 5/10 | N/A | N/A | 7/10 | |
| Kidneys: | Pelvic dilatation, slight | 2/10e | 1/1 | 2/2 | 0/10 |
| Lungs: | Alveolar emphysema, minimal | 1/10 | / | / | 1/10 |
| Hyperplasia of BALT, minimal | 1/10 | / | / | 0/10 | |
| Thymus: | Acute hemorrhage, mild | 1/10e | / | / | 0/10 |
| Uterus: | Dilatation | 2/10e | / | / | 2/10 |
/, not examined; BALT, bronchus associated lymphoid tissue; N/A, not applicable (only animals with gross lesions were examined).
Data represent incidence of the observation (number of animals with observation per number of animals observed).
Organs without lesions in 10/10 control or high-dose animals not shown.
Matching superscripts represent findings observed in the same animal.