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. 2019 Jul 9;10(43):4424–4436. doi: 10.18632/oncotarget.27040

Figure 1. Tris DBA reduces cell viability in GNAQ/GNA11 mutant cell lines.

Figure 1

Tris DBA selectively inhibits cell proliferation of GNAQ and GNA11-mutant cells. 92.1(Gq mutant), Omm1.3 (Gq mutant), OMM1 (G11 mutant) and Mel290 (Wild Type) uveal melanoma cell lines were treated with 0, 1.1, 2.7, 5.5 and 10.9 μM of Tris DBA for 24 hours. CCK-8 reagent from Dojindo Molecular Technologies (Rockville, MD, USA), was added after drug treatment to the cells and OD was read at 450 nm. Drug treated samples were presented as percent of control. Results represent the mean of three independent experiments.