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(A) Inhibition of H3-PGE2 binding to EP2 receptors by TG8–69. (B) TG8–69 showed >10,000 nM Schild potency in the TR-FRET assay for other Gas-coupled prostanoid receptors, DP1, EP4, and IP. The KBs are estimated from fold changes to agonist EC50 caused by 10 uM compound. Agonists were PGE2 for EP2 and EP4, BW245C for DP1, and iloprost for IP (n = 3–4 repeats in duplicate).
