Figure 7.

GluK1 receptors sensitive to philantotoxin control MF excitability. A, Consecutive traces showing antidromic spikes recorded in granule cells on stimulation of MF in stratum lucidum before and during application of UBP 302 (note that the stimulus strength was set to obtain >50% of successes). B, Summary plot of UBP 302 effects on success rate (n = 7). C, D, In cells with <50% of successes, ATPA enhanced MF excitability and the success rate (n = 7). E, F, PhTx (3 μm) mimicked the effects of UBP 302 (n = 7). G, H, In the presence of philantotoxin, UBP was not effective (n = 7). ***p < 0.001. Error bars indicate SEM.