Table 1.

Activation and fast inactivation properties of WT and mutant hNa_v1.7 channels

	U0124		U0126
	V1/2 (mV)	k (mV)	V1/2 (mV)	k (mV)
WT
Activation	−27.5 ± 1.8	7.0 ± 0.4	−20.9 ± 1.8*	7.8 ± 0.4
Inactivation	−85.8 ± 1.4	6.4 ± 0.1	−81.0 ± 1.7*	7.2 ± 0.3*
T531A, S608A
Activation	−24.9 ± 1.2	7.6 ± 0.2	−21.5 ± 0.7*	8.1 ± 0.3
Inactivation	−84.8 ± 0.8	6.0 ± 0.2	−83.6 ± 0.9	7.1 ± 0.2*
T531A, S535A, S608A
Activation	−23.1 ± 1.6	8.0 ± 0.3	−21.9 ± 1.6	7.8 ± 0.3
Inactivation	−82.4 ± 1.2	6.3 ± 0.1	−83.0 ± 1.5	6.7 ± 0.2
T531A, S608A, S712A
Activation	−22.3 ± 0.8	7.9 ± 0.2	−22.3 ± 0.9	7.8 ± 0.1
Inactivation	−82.1 ± 0.9	6.5 ± 0.1	−83.1 ± 1.3	6.7 ± 0.1

*p < 0.05 versus U0124.