Figure 8.

Diagrammatic model showing the influence of granule cell maturity on vulnerability to SE-induced structural plasticity. In this model, fully mature cells (born at P7; top row) are resistant to SE-induced remodeling. Some DGCs born at P28 (4 weeks of age at SE; second row), however, show abnormal hilar basal dendrites (HBDs) (b) and MFS (s). Those born on P42 (2 weeks of age at SE; third row) display extensive HBD formation 4 weeks after SE and to a lesser extent contribute to MFS seen 4 weeks after pilocarpine treatment. DGCs born 4 d after SE (P60 injections; bottom row) exhibit both HBDs and ectopic migration without MFS at 4 weeks after SE, but they develop MFS by 10 weeks. The model assumes that changes seen at 4 weeks remain stable for RV-GFP injections before SE (top 3 rows) as only animals administered RV-GFP after SE (bottom row) were examined at the 10 week time point in this study.